Our Research

How it began

 

In late 2015, our researchers were approached by a patient who, though she had been in menopause for four years, was determined to start a family. Inspired by her conviction, they decided to challenge the conventional notion that a woman is born with only a certain amount of eggs.

Since the 1950s, it's been the dogma that women are born with a fixed number of eggs. It was from this limited “bank account” of eggs that a woman would “draw down” with each ovulation, and lose other eggs due to genetic or environmental damage. When her “bank account” got too low, her body and mind would stop producing estrogen, leading to the symptoms of menopause, and all the associated health conditions that go along with it.

Determined to support our patient in her desire to regain fertility, our researchers presented the novel idea that menopause was not a “natural” process, but a result of damage and deterioration experienced by the woman in the aging process. They believed that this damage could be healed, and that full feminine fertility could be restored and rejuvenated.

To achieve an innovative result, they knew they would have to utilize an innovative procedure. They chose to avoid traditional hormone therapies, and opted instead to attempt to heal the woman’s body using the natural supply of growth factors within her own genetic material - her own blood.

 

The Idea Worked

Only a few months after receiving her first PRP injection, her body was once again capable of generating healthy, fertile eggs. She has since become the first woman to conceive a child through the Ovarian Rejuvenation treatment..

Over time, our researchers discovered that the treatment was also having an additional effect - the overall state of feminine mental and physical health appeared to improve significantly with the restoration of youthful hormone levels. It is our intention in these Ovarian Rejuvenation trials to evaluate and monitor the extent and duration of these positive health changes, in order to more accurately understand the connections between fertility and overall cognitive and physiological health in women.

The Science Behind the Research:

The Traditional (and Inaccurate) Theory of Menopause

Since the 1950s, it’s been the dogma that women are born with a fixed eggs. It was from this limited “bank account” of eggs that a woman would “draw down” with each ovulation, and lose other eggs due to genetic or environmental damage.

When her “bank account” got too low, her body and mind would stop producing estrogen, leading to the symptoms of menopause, and all the associated health conditions that go along with it.

However, a 2006 research study in mice by Dr. Jonathan Tilly revealed that female mice continue to produce egg cells well past menopause – just at a very reduced rate. This indicated that the mice were still capable of becoming pregnant, but with a very low likelihood. This also indicated that the female mice had not lost fertility – they had just lost the levels of hormones needed to produce strong eggs.

The results of Dr. Tilly’s research were then compared to the experiences of female cancer survivors who had lost fertility while undergoing strong doses of harmful radiation during chemotherapy. Months and years later, these same women mysteriously regained fertility after receiving bone marrow transplantations.

Were bone marrow transplantation giving women new egg cells? As impossible as it sounded, the idea had to be tested, and tested it was – only to be proven false. However, something was enabling these women to regain their fertility – but what?

 

The final conclusions of Dr. Tilly’s research offered two possibilities:

  • That factors in the bone marrow transplants, such as the growth factors present in PRP transfusions, were awakening a hidden storage of dormant eggs within the women’s bodies.
  • Or, the most exciting possibility: that these growth factors were actually rejuvenating the body’s potential to develop new eggs.

When our researchers discovered the work of Dr. Tilly, they knew that they had the missing link. PRP transfusions contain large amounts of natural growth factors, so no matter which possibility was true, they knew that they could restore fertilility.

Now, having demonstrated the success of the PRP treatment to rejuvenate fertility in women, the Inovium Ovarian Rejuvenation trials will evaluate what type of and for how long this rejuvenation occurs and the extent of the health benefits experienced by women as a result.